In Nature Immunology
faculty members Sonal Srikanth and Yousang Gwack
report a new role for a Ca2+ sensor molecule (STIM1)
to keep the immune system in check by retaining STING (stimulator of interferon genes) in the ER.
STIM1 moonlights as an anchor for STING Nature Immunology 20, 152–162 (2019)
Dr. Baljit Khakh has been named an Allen Institute Distinguished investigator.
Dr. Khakh and his laboratory team will study the suite of genes each astrocyte turns on or off, cell by cell, in an attempt to dispel the myth that all astrocytes are created equal. They will ask how astrocytes influence nearby neuron activity using novel methods created in the Khakh lab.
Dr. Tamir Gonen, an electron crystallography expert at UCLA, teamed up with colleagues, along with Brian Stoltz at Caltech, to see whether the Gonen lab’s electron microscopy imaging methods would work with smaller organic molecules. The California team reported it worked nearly every time, delivering a resolution on par with x-ray crystallography. Scientists say the new technique could revolutionize fields both inside and outside of research.
You can read the Department's 2018 accomplishments in the PDF:
2018 Department of Physiology Highlights
“Chemical synthesis coupled to in vivo validation to improve a small molecule that targets pathogenic blood vessels in diverse diseases”
Guo Cheng, Ph.D. (Sun Lab)