In the News

Sonal Srikanth, Yousang Gwack and colleagues report that NKD2 mediates stimulation-dependent ORA1 trafficking to augment sustained Ca entry in T Cells. Cell Reports Aug 2021

Bal Khakh’s Lab showed that behavior-modifying peripheral neuroinflammation alters gene expression in astrocytes and microglia, but not neurons. Cell Reports Aug 2021

Riccardo Olcese’s Lab identified distinct roles for the four voltage sensors in the CaV1.1 calcium channel of skeletal muscle J Gen Physiol Sept 2021

Laura DeNardo received a 2021 Klingenstein-Simons Fellowship Award in Neuroscience.

Ambre Bertholet received a MIRA (R35) Award from the NIGMS for her project on Mechanisms of Regulation of Mitochondrial H+ Leak and Thermogenesis

Steve Cannon received the Biophysical Society 2022 Award in the Biophysics of Health and Disease

Shimon Weiss received the 2022 Kazuhiko Kinosita Award in Single-Molecular Biophysics from the Biophysical Society

Featured Faculty

Ambre Bertholet, Ph.D.

The UCLA Department of Physiology is pleased to announce the appointment of Ambre Bertholet, Ph.D. starting December 1, 2020.

Dr. Bertholet was trained in Toulouse, France at the Université Paul Sabatier. She earned her B.S. in Cell Biology and Physiology, M.S. in Gene Cells and Development, and her Ph.D. in Biology, Health and Biotechnologies. Subsequently, she did her postdoctoral training with Dr. Yuiry Kirichok at UC San Francisco and is currently an Assistant Research Physiologist.

Her interest in mitochondria was sparked as a graduate student in the laboratory of Pr. Pascale Belenguer. During her Ph.D. research, she analyzed the influence of mitochondrial dynamics on neuronal maturation and functioning.

As a postdoctoral trainee, she focused on another important aspect of mitochondrial physiology – the transport of ions and metabolites across the mitochondrial membranes. In the Kirichok lab, she developed a patch-clamp method for directly measuring proton movement across the inner mitochondrial membrane. This innovation enabled Dr. Bertholet to identify novel transport mechanisms for the mitochondrial H+ leak responsible for mitochondrial heat production and metabolic regulation of energy expenditure.

We look forward to having Dr. Bertholet in the Physiology Department.