PNAS Cover (March 28, 2018) from the Gonen Lab is a computer-generated atomic model of a protein scaffolding system.
Small proteins, such as those found throughout a cell, are not amenable to detailed analysis by cryo-electron microscopy (cryo-EM).
Yuxi Liu et al. designed a self-assembling protein scaffolding system that enables the analysis of small proteins by cryo-EM.
Using the scaffolding system, the authors visualized the structure of a small protein in near-atomic detail,
potentially enabling the visualization of cellular proteins by cryo-EM.
See the article by Liu et al. on pages 3362–3367. Image courtesy of Shane Gonen
Ms. Joselyn Soto, a Ph.D. student from the Khakh lab, received the 2018-2019 Buchwald Award and a NSF Graduate Fellowship for 2018-2022.Dr. Jun Nagai, also from the Khakh lab, recently received the Ben Barres Trainee Award CHSL
Please join us in welcoming Assistant Professor Lindsay De Biase, Ph.D., to the Physiology team!
Convergence of Clinically Relevant Manipulations on Dopamine-regulated Prefrontal Activity Underlying Stress-coping Responses
- Scott Wilke, M.D., Ph.D.
Clinical Fellow, UCSF