Physiology seeks to understand biological function spanning the range from molecular mechanisms to medical problems.
No other field has such an important task or is as cross-disciplinary in nature.
The Department of Physiology is an internationally recognized research center in which this broad perspective is collaboratively
embraced by the entire faculty.
Areas of systems level investigation include the cardiovascular, gastrointestinal, endocrine, immune and central nervous systems.
We also explore cellular processes such as synaptic transmission, the immune response and muscle excitation-contraction coupling
as well as molecular mechanisms of ion channels and transporters.
At the level of disease, efforts are focused on spinocerebellar ataxia, epilepsy, blindness, cardiac hypertrophy and failure, diabetes,
immune deficiencies, muscular dystrophy, channelopathies, transport deficiencies and others.
Research approaches are multidisciplinary, including electrophysiology and biophysics, molecular, cellular and whole-animal imaging,
proteomics and X-ray crystallography Moreover, the Department has a strong track record of being at the forefront of emerging new approaches.
There are active collaborative ties with clinical departments and institutes throughout the David Geffen School of Medicine,
including the Cardiovascular Research Laboratory and the Departments of Medicine, Pharmacology, Neurology and Anesthesiology.
Recent Publications of Physiology Faculty
Nancy Wayne, PhD
and her lab's research have been highlighted in the February 01, 2016 issue of
Chemical used to replace BPA in plastic accelerates embryonic development, disrupts reproductive system
A video is also available: BPA vs BPS
Mice with an NaV1.4 sodium channel null allele have latent myasthenia, without susceptibility to periodic paralysis.
Wu F, Mi W, Fu Y, Struyk A, Cannon SC.
Brain. 2016 Jun;139(Pt 6):1688-99. doi: 10.1093/brain/aww070. Epub 2016 Apr 5.
Astrocyte scar formation aids central nervous system axon regeneration.
Anderson MA, Burda JE, Ren Y, Ao Y, O'Shea TM, Kawaguchi R, Coppola G, Khakh BS, Deming TJ, Sofroniew MV.
Nature. 2016 Apr 14;532(7598):195-200. doi: 10.1038/nature17623. Epub 2016 Mar 30
Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice.
Jiang R, Diaz-Castro B, Looger LL, Khakh BS.
J Neurosci. 2016 Mar 23;36(12):3453-70. doi: 10.1523/JNEUROSCI.3693-15.2016.
A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals.
Srikanth S, Kim KD, Gao Y, Woo JS, Ghosh S, Calmettes G, Paz A, Abramson J,Jiang M, Gwack Y.
Sci Signal. 2016 Mar 22;9(420):ra31. doi: 10.1126/scisignal.aac9171.
UCLA Physiology Department Open Positions
Assistant Project Scientist