Dr. Thomas Vondriska
Proteonomics and Systems Biology of
Heart
Disease
BH 577A, CHS
310-206-4072
310-206-4188 Lab
tvondriska@mednet.ucla.edu
Visit my Lab
Research Interests:
Cellular behavior is an emergent property of an interconnected network of proteins, nucleotides, metabolites and other molecules. To understand this emergence, we must understand how large sets of molecules relate to each other to engender phenotype. My lab is focused on the complex phenotypic state of heart disease, which remains a leading cause of morbidity and mortality in the developed world. Specifically, we are using proteomics to deconvolute protein interaction networks within the cardiac cell (specific ongoing projects include non-receptor tyrosine kinases). Furthermore, we are examining post-translational modifications responsible for the flow of information through these networks, using mass spectrometry to examine phosphorylation. Biochemistry and molecular biology approaches are used to functionally define relationships among groups of proteins in different sectors of the network. Lastly, the effects of disease (such as acute myocardial infarction and heart failure) on the behavior of protein interaction networks is examined at the whole animal and proteomic level.
Representative Publications:
Han Z, Vondriska TM, Yang L, MacLellan WR, Weiss JN, Qu Z. Signal transduction network motifs and biological memory. J Theor Biol. 2007; 246:755–761.
Taylor CF, Paton NW, Lilley KS, Binz P-A, Julian RK, Jones AR, Zhu W, Apweiler R, Aebersold R, Deutsch EW, Dunn MJ, Heck AJR, Leitner A, Macht M, Mann M, Martens L, Neubert TA, Patterson SD, Ping P, Seymour SL, Souda P, Tsugita A, Vandekerckhove J, Vondriska TM, Whitelegge, Wilkins MR, Xenarios I, Yates JR, Hermjakob H. The minimum information about a proteomics experiment (MIAPE). Nat Biotechnol. 2007; 25:887–893.
Berhane BT, Zong C, Liem DA, Huang A, Le S, Edmondson RD, Jones RC, Qiao X, Whitelegge JP, Ping P, Vondriska TM. Cardiovascular-related proteins identified in the HUPO plasma proteome project pilot phase. Proteomics. 2005; 3520–3530.
Synapse in Xenopus
Nerve-muscle cell culture
Freeze-etch of frog nmj
