Publications
Recent (2005 onwards)
Srikanth S, Yee MK, Gwack Y*, Ribalet B*. The third transmembrane segment of ORAI1 modulates Ca2+-release-activated Ca2+ (CRAC) channel gating and permeation. Journal of Biol Chem, in press. *Corresponding Author
Kim KD, Srikanth S, Yee MK, Mock C, Lawson GW, Gwack Y. Orai1 deficiency impairs activated T cell death and enhances T cell survival. Journal of Immunology, in press
Newton RH, Leverrier S, Srikanth S, Gwack Y, Cahalan MD, Walsh CM. Protein kinase D orchestrates the activation of DRAK2 in response to T cell receptor induced extracellular calcium uptake and mitochondrial reactive oxygen generation. Journal of Immunology, 2011 Jan; 186(2):940-40.
Srikanth S, Jung HJ, Kim KD, Souda P, Whitelegge JP, Gwack Y. A novel EF hand-containing protein, CRACR2A is a cytosolic Ca2+ sensor that stabilizes active conformation of the CRAC channel. Nature Cell Biology, 2010 May; 12(5): 436-446.
Srikanth S, Jung HJ, Ribalet B, Gwack Y. The intracellular loop of Orai1 plays a central role in fast inactivation of CRAC channels. J Biol Chem. 2010 Feb 12; 285(7): 5066-75. PMCID: PMC2836109
E X, Hwang S, Oh S, Lee JS, Jeong JH, Gwack Y, Kowalik TF, Sun R, Jung JU, Liang C. Viral Bcl-2-mediated evasion of autophagy aids chronic infection of gammaherpesvirus 68. PLos Pathog. 2009, 5(10): e1000609. PMCID: PMC2752191
Gwack Y*, Srikanth S*, Oh-hora M*, Hogan PG, Lamperti E, Yamashita M, Gelinas C, Neems DS, Sasaki Y, Feske S, Prakriya M, Rajewsky K, Rao A. Hair loss and defective T- and B-cell function in mice lacking Orai1. Molecular and Cellular Biology. 2008 Sep 28;28(17):5209-22 * Equal contribution. 2008 Sep 28;28(17):5209-22.
Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-hora M, Rao A, Samelson LE. Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T cells; signaling puncta and distal caps. Molecular Biology of the Cell. 2008, April 30;19(7):2802-17.
Gwack Y, Feske S, Srikanth S, Hogan PG, Rao A. Signalling to transcription: Store-operated Ca(2+) entry and NFAT activation in lymphocytes. Cell Calcium. 2007 Aug;42(2):145-56.
Gwack Y*, Srikanth S*, Feske S, Cruz-Guilloty F, Oh-hora M, Neems DS, Hogan PG, Rao A. Biochemical and functional characterization of Orai proteins. J Biol Chem. 2007 Jun 1;282(22):16232-43. * Equal contribution
Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill D, Ambudkar IS. Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components, J Biol Chem. 2007 Mar 23;282(12):9105-16.
Prakriya M*, Feske S*, Gwack Y*, Srikanth S, Rao A, Hogan PG. Orai1 is an essential component of the CRAC channel pore, Nature. 2006 Sep 14;443(7108):230-3. *Equal Contribution.
Feske S*, Gwack Y*, Prakriya M, Srikanth S, Puppel S-H, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A. A mutation in Orai1 causes immune deficiency by abrogating store-operated Ca2+ entry and CRAC channel function, Nature (Article), 2006 May 11;441(7090):179-85.
Gwack Y*, Sharma S*, Nardone J, Tanasa B, Iuga A, Srikanth S, Okamura H, Bolton D, Feske S, Hogan PG, Rao A. A genome-wide Drosophila RNAi screen identifies DYRK as a novel regulator of NFAT. Nature (letter), 2006 Jun 1;441(7093):646-50.
Before 2005
Chang H, Gwack Y, Kingston D, Souvlis J, Liang X, Means RE, Cesarman E, Hutt-Fletcher L, Jung JU. Activation of CD21 and CD23 gene expression by Kaposi's sarcoma-associated herpesvirus RTA. J Virol. 2005 Apr; 79(8):4651-63.
Lee SH, Chung YH, Cho NH, Gwack Y, Feng P, Jung JU. Modulation of T-cell receptor signal transduction by herpesvirus signaling adaptor protein. Mol Cell Biol. 2004 Jun; 24(12):5369-82.
Gwack Y, Nakamura H, Lee SH, Souvlis J, Yustein JT, Gygi S, Kung HJ, Jung JU. PARP-1 and Ste20-like hKFC act as transcriptional repressors for gamma-2 herpesviral lytic replication. Mol Cell Biol. 2003 Nov; 23(22):8282-94
Nakamura H, Lu M, Gwack Y, Souvlis J, Zeihner SL, Jung JU. Global Changes in KSHV gene expression patterns following expression of a tetracycline-inducible RTA transactivator. J Virol. 2003 Apr; 77(7):4205-20.
Gwack Y, Baek HJ, Nakamura H, Lee SH, Meisterernst M, Roeder RG, Jung JU. Principal role of TRAP/Mediator and SWI/SNF complexes in KSHV RTA-mediated lytic replication. Mol Cell Biol. 2003 Mar; 23(6): 2055-2067.
Hwang S, Lee D, Gwack Y, Min H, Choe J. Kaposi's sarcoma-associated herpesvirus K8 protein interact with hSNF5. J. Gen. Virol. 2003 Mar;84(Pt 3):665-76.
Byun H, Gwack Y, Hwang S, Choe J. Kaposi's sarcoma-associated herpesvirus open reading frame (ORF) 50 transactivates K8 and ORF57 promoters via heterogeneous response elements. Mol Cells. 2002 Oct 31; 14(2):185-91.
Lim C, Sohn H, Lee D, Gwack Y, Choe J. Functional dissection of latency-associated nuclear antigen 1 of Kaposi's sarcoma-associated herpesvirus involved in latent DNA replication and transcription of terminal repeats of the viral genome. J Virol. 2002 Oct; 76(20):10320-31.
Gwack Y, Hwang S, Lim C, Won YS, Lee CH, Choe J. Kaposi's Sarcoma-associated herpesvirus open reading frame 50 stimulates the transcriptional activity of STAT3. J Biol Chem. 2002 Feb 22; 277(8):6438-42.
Hwang S, Gwack Y, Byun H, Lim C, Choe J. The Kaposi's sarcoma-associated herpesvirus K8 protein interacts with CREB-binding protein (CBP) and represses CBP-mediated transcription. J Virol. 2001 Oct; 75(19):9509-16.
Gwack Y, Hwang S, Byun H, Lim C, Kim JW, Choi EJ, Choe J. Kaposi's sarcoma-associated herpesvirus open reading frame 50 represses p53-induced transcriptional activity and apoptosis. J Virol. 2001 Jul; 75(13):6245-8.
Lim C, Gwack Y, Hwang S, Kim S, Choe J. The transcriptional activity of cAMP response element-binding protein-binding protein is modulated by the latency associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus. J Biol Chem. 2001 Aug 17; 276(33):31016-22.
Gwack Y, Byun H, Hwang S, Lim C, Choe J. CREB-binding protein and histone deacetylase regulate the transcriptional activity of Kaposi's sarcoma-associated herpesvirus open reading frame 50. J Virol. 2001 Feb; 75(4):1909-17.
Lim C, Sohn H, Gwack Y, Choe J. Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity. J Gen Virol. 2000 Nov; 81(Pt 11):2645-52.
Park J, Seo T, Hwang S, Lee D, Gwack Y, Choe J. The K-bZIP protein from Kaposi's sarcoma-associated herpesvirus interacts with p53 and represses its transcriptional activity. J Virol. 2000 Dec; 74(24):11977-82.
Gwack Y, Yoo H, Song I, Choe J, Han JH. RNA-Stimulated ATPase and RNA helicase activities and RNA binding domain of hepatitis G virus nonstructural protein 3. J Virol. 1999 Apr; 73(4):2909-15.
Gwack Y, Kim DW, Han JH, Choe J. DNA helicase activity of the hepatitis C virus nonstructural protein 3. Eur J Biochem. 1997 Nov 15; 250(1):47-54.
Kim DW, Kim J, Gwack Y, Han JH, Choe J. Mutational analysis of the hepatitis C virus RNA helicase. J Virol. 1997 Dec; 71(12):9400-9.
Kim DW, Gwack Y, Han JH, Choe J. Towards defining a minimal functional domain for NTPase and RNA helicase activities of the hepatitis C virus NS3 protein. Virus Res. 1997 May; 49(1):17-25.
Gwack Y, Kim DW, Han JH, Choe J. Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein. Biochem Biophys Res Commun. 1996 Aug 14; 225(2):654-9.
Kim DW, Gwack Y, Han JH, Choe J. C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity. Biochem Biophys Res Commun. 1995 Oct 4; 215(1):160-166.
Gwack Y, Kim DW, Han JH, Choe J. NTPase activity of hepatitis C virus NS3 protein expressed in insect cells. Mol Cells. 1995 5:171–175.