Earl Homsher, PhD
Position Title:Professor Emeritus, Physiology
Research Interests:
Regulation of contraction; single motor molecule force displacement measurements; the molecular biology of hypertrophic cardiomyopathy; single myofibril mechanics and kinetics; in vitro motility; single molecule force measurements and transient kinetics of non- muscle myosin IIB and myosin 18.
Representative Publications:
Sumandea M, Vahebi S, Sumandea C, Garcia-Cazarin M, Staidle J, Homsher E. (2009) Impact of cardiac troponin T N-terminal deletion and phosphorylation on myofilament function Biochemistry. 48(32):7722-31.
Siththanandan VB, Tobacman LS, Van Gorder N, Homsher E. (2009) Mechanical and kinetic effects of shortened tropomyosin reconstituted into myofibrils Pflugers Arch. Aug;458(4):761-76.
Takagi Y, Homsher E, Goldman Y, Shuman H. (2006) Force generation in single conventional actomyosin complexes under high dynamic load Biophys J. 90(4):1295-30.7