Ken Philipson
Biophysics and Structural Studies are interdisciplinary fields incorporating the structure, functions and interactions of biologically important macromolecules. We utilize a variety of techniques to answer physiologically relevant questions, including X-ray crystallography, fluorescence imaging and spectroscopy, as well as a number of electrophysiological, biochemical and molecular biology-based approaches. The Department includes a number of internationally recognized researchers investigating cellular transport, excitation-contraction coupling, and synaptic transmission, to name a few.
Neonatal cardiac myocytes expressing the calcium regulatory domain of the sodium-calcium exchanger flanked by YFP and CFP. The fluorscence ratio YFP/CFP changes during physiological calcium transients indicating conformational changes of the protein. See Biophys. J. 87:899-906, 2004 for details.
Dr. Ken Philipson
Integrative Physiology
Imaging & Optics
Structural Studies & Biophysics
Department of Physiology
Cell Signaling
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