Biophysics and Structural Studies are interdisciplinary fields incorporating the structure, functions and interactions of biologically important macromolecules. We utilize a variety of techniques to answer physiologically relevant questions, including X-ray crystallography, fluorescence imaging and spectroscopy, as well as a number of electrophysiological, biochemical and molecular biology-based approaches. The Department includes a number of internationally recognized researchers investigating cellular transport, excitation-contraction coupling, and synaptic transmission, to name a few.
Neonatal cardiac myocytes expressing the calcium regulatory domain of
the sodium-calcium exchanger flanked by YFP and CFP. The fluorscence
ratio YFP/CFP changes during physiological calcium transients
indicating conformational changes of the protein. See Biophys. J.
87:899-906, 2004 for details.
Dr. Ken Philipson