The 7 papers that have been cited for more than 300 times are marked by•••
- Allikmets, R.; Singh, N.; Sun, H.;
Shroyer, N. F.; Hutchinson, A.; Chidambaram, A.; Gerrard, B.; Baird, L.;
Stauffer, D.; Peiffer, A.; Rattner, A.; Smallwood, P.; Li, Y.; Anderson, K. L.;
Lewis, R. A.; Nathans, J.; Leppert, M.; Dean, M.; Lupski, J. R., A
photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in
recessive Stargardt macular dystrophy. Nature Genetics 1997,
15 (3), 236-46.•••
- Sun, H.; Macke, J. P.; Nathans, J., Mechanisms of spectral tuning in the mouse green cone pigment. Proc
Natl Acad Sci U S A 1997, 94 (16), 8860-5.
- Chen, S.; Wang, Q. L.; Nie, Z.; Sun, H.; Lennon, G.; Copeland, N. G.; Gilbert, D. J.; Jenkins, N. A.; Zack, D.
J., Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron
1997, 19 (5), 1017-30.•••
- Sun, H.; Gilbert, D. J.; Copeland, N. G.; Jenkins, N. A.; Nathans, J., Peropsin, a novel visual pigment-like
protein located in the apical microvilli of the retinal pigment epithelium.
Proc Natl Acad Sci U S A 1997, 94 (18), 9893-8.
- Sun, H.; Nathans, J., Stargardt's ABCR is localized to the disc membrane of retinal rod outer segments. Nature
Genetics 1997, 17 (1), 15-6.
- Sherman, P. M.; Sun, H.; Macke, J. P.; Williams, J.; Smallwood, P. M.; Nathans, J., Identification and
characterization of a conserved family of protein serine/threonine phosphatases
homologous to Drosophila retinal degeneration C. Proc Natl Acad Sci U
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- Sun, H.; Molday, R. S.; Nathans, J., Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the
photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease. J Biol Chem 1999, 274
(12), 8269-81.•••
- Rattner, A.; Sun, H.; Nathans, J., Molecular genetics of human retinal disease. Annu Rev Genet
1999, 33, 89-131.
- Xu, S.; Ladak, R.; Swanson, D. A.; Soltyk, A.; Sun, H.; Ploder, L.; Vidgen, D.; Duncan, A. M.; Garami, E.;
Valle, D.; McInnes, R. R., PHR1 encodes an abundant, pleckstrin homology domain-containing integral membrane protein in the photoreceptor outer
segments. J Biol Chem 1999, 274 (50), 35676-85.
- Sun, H.; Smallwood, P. M.; Nathans, J., Biochemical defects in ABCR protein variants associated with human retinopathies. Nature Genetics 2000, 26 (2), 242-6.
- Sun, H.; Nathans, J., ABCR: rod photoreceptor-specific ABC transporter responsible for Stargardt disease. Methods
Enzymol 2000, 315, 879-97.
- Sun, H.; Nathans, J., Mechanistic
studies of ABCR, the ABC transporter in photoreceptor outer segments
responsible for autosomal recessive Stargardt disease. J Bioenerg
Biomembr 2001, 33 (6), 523-30.
- Sun, H.; Nathans, J., ABCR, the
ATP-binding cassette transporter responsible for Stargardt macular dystrophy,
is an efficient target of all-trans-retinal-mediated photooxidative damage in
vitro. Implications for retinal disease. J Biol Chem 2001,
276 (15), 11766-74.
- Sun, H.; Nathans, J., The challenge
of macular degeneration. Scientific American 2001, 285
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- Sun, H.; Tsunenari, T.; Yau, K. W.;
Nathans, J., The vitelliform macular dystrophy protein defines a new family of
chloride channels. Proc Natl Acad Sci U S A 2002,
99 (6), 4008-13.•••
This paper discovered a new family of anion channels in vertebrate and invertebrate animals and was highlighted in the following scientific news:
Featured in the Howard Hughes Medical Institute News
Rated as Must ReadbyFaculty of 1000 Biology
This anion channel family participates in diverse physiological functions such as tonic GABA release from glia (Science
330:790-6, 2010) and sweat production (PNAS 109: 1199-203,2012).
The crystal structures of this new type of anion channels have been determined (Science 346:355-9, 2014
and Nature 516: 213-8, 2014)
- Tsunenari, T.; Sun, H.; Williams, J.; Cahill, H.; Smallwood, P.; Yau, K. W.; Nathans, J., Structure-function
analysis of the bestrophin family of anion channels. J Biol Chem
2003, 278 (42), 41114-25.
- Jin, M.; Li, S.; Moghrabi, W. N.; Sun, H.; Travis, G. H., RPE65 is the retinoid isomerase in bovine retinal pigment
epithelium. Cell 2005, 122 (3), 449-59.•••
- Yang, Z.; Camp, N. J.; Sun, H.;
Tong, Z.; Gibbs, D.; Cameron, D. J.; Chen, H.; Zhao, Y.; Pearson, E.; Li, X.;
Chien, J.; Dewan, A.; Harmon, J.; Bernstein, P. S.; Shridhar, V.; Zabriskie, N.
A.; Hoh, J.; Howes, K.; Zhang, K., A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.
Science2006, 314 (5801), 992-3.•••
- Kawaguchi, R.; Yu, J.; Honda, J.; Hu, J.;
Whitelegge, J.; Ping, P.; Wiita, P.; Bok, D.; Sun, H., A membrane
receptor for retinol binding protein mediates cellular uptake of vitamin A. Science
(Research Article)2007, 315 (5813), 820-5.•••
This article was highlighted in the following scientific news:
Science News, Science January 25, 2007
Research Highlights, Nature 445: 462, 2007
Editors Choice, Science STKE 373:55, 2007
Research Spotlight, ACS Chemical Biology 2:142, 2007
This week in Science, Science 315: 735, 2007
Research News, The Scientist, January 25, 2007
Rated as Exceptional by Faculty
of 1000 Biology
- Noble, B. R.; Babiuk, R. P.; Clugston, R.
D.; Underhill, T. M.; Sun, H.; Kawaguchi, R.; Walfish, P. G.; Blomhoff,
R.; Gundersen, T. E.; Greer, J. J., Mechanisms of action of the congenital
diaphragmatic hernia-inducing teratogen nitrofen. Am J Physiol 2007,
293 (4), L1079-87.
- Yu, J.; Wiita, P.; Kawaguchi, R.; Honda,
J.; Jorgensen, A.; Zhang, K.; Fischetti, V. A.; Sun, H., Biochemical
analysis of a common human polymorphism associated with age-related macular
degeneration. Biochemistry 2007, 46 (28),
8451-61.
- Kawaguchi, R.; Yu, J.; Wiita, P.;
Ter-Stepanian, M.; Sun, H., Mapping the membrane topology and
extracellular ligand binding domains of the retinol binding protein receptor. Biochemistry
2008, 47 (19), 5387-95.
- Kawaguchi, R.; Yu, J.; Wiita, P.; Honda,
J.; Sun, H., An essential ligand-binding domain in the membrane receptor
for retinol-binding protein revealed by large-scale mutagenesis and a human
polymorphism. J Biol Chem 2008, 283 (22),
15160-8.
- Pavone, M. E.; Reierstad, S.; Sun, H.;
Milad, M.; Bulun, S. E.; Cheng, Y. H., Altered retinoid uptake and action
contributes to cell survival in endometriosis. J Clin Endocrinol Metab
2010, 95 (11), E300-9.
- Ufret-Vincenty, R. L.; Aredo, B.; Liu, X.;
McMahon, A.; Chen, P. W.; Sun, H.; Niederkorn, J. Y.; Kedzierski, W.,
Transgenic mice expressing variants of complement factor H develop AMD-like
retinal findings. Invest Ophthalmol Vis Sci 2010, 51
(11), 5878-87.
- Kawaguchi, R.; Sun, H., Techniques to study specific cell-surface
receptor-mediated cellular vitamin A uptake. Methods Mol Biol 2010, 652, 341-61.
- Kawaguchi, R.; Yu, J.; Ter-Stepanian, M.;
Zhong, M.; Cheng, G.; Yuan, Q.; Jin, M.; Travis, G. H.; Ong, D.; Sun, H.,
Receptor-mediated cellular uptake mechanism that couples to intracellular
storage. ACS Chemical Biology 2011, 6 (10),
1041-51.
- Sun, H.; Kawaguchi, R., The
membrane receptor for plasma retinol-binding protein, a new type of
cell-surface receptor. Int Rev Cell Mol Biol 2011, 288,
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- Casey, J.; Kawaguchi, R.; Morrissey, M.; Sun,
H.; McGettigan, P.; Nielsen, J. E.; Conroy, J.; Regan, R.; Kenny, E.;
Cormican, P.; Morris, D. W.; Tormey, P.; Chroinin, M. N.; Kennedy, B. N.;
Lynch, S.; Green, A.; Ennis, S., First implication of STRA6 mutations in
isolated anophthalmia, microphthalmia, and coloboma: a new dimension to the
STRA6 phenotype. Hum Mutat 2012, 32 (12), 1417-26.
- Kawaguchi, R.; Zhong, M.; Kassai, M.;
Ter-Stepanian, M.; Sun, H., STRA6-catalyzed vitamin A influx, efflux and
exchange. J Membr Biol. 2012, 245 (11),
731-745.
- Sun, H., Membrane receptors and
transporters involved in the function and transport of vitamin A and its
derivatives. Biochim Biophys Acta 2012, 1821
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- Shaw, P. X.; Zhang, L.; Zhang, M.; Du, H.;
Zhao, L.; Lee, C.; Grob, S.; Lim, S. L.; Hughes, G.; Lee, J.; Bedell, M.;
Nelson, M. H.; Lu, F.; Krupa, M.; Luo, J.; Ouyang, H.; Tu, Z.; Su, Z.; Zhu, J.;
Wei, X.; Feng, Z.; Duan, Y.; Yang, Z.; Ferreyra, H.; Bartsch, D. U.; Kozak, I.;
Lin, F.; Sun, H.; Feng, H.; Zhang, K., Complement factor H genotypes
impact risk of age-related macular degeneration by interaction with oxidized
phospholipids. Proc Natl Acad Sci U S A 2012, 109
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- Zhong, M.; Kawaguchi, R.; Kassai, M.; Sun,
H., Retina, retinol, retinal and the natural history of vitamin A as a
light sensor. Nutrients 2012, 4 (12), 2069-96.
- Kawaguchi, R.; Zhong, M.; Sun, H.,
Real-time analyses of retinol transport by the membrane receptor of plasma
retinol binding protein. J Vis Exp 2013,
(71), e50169.
- Kawaguchi, R.; Zhong, M.; Kassai, M.;
Ter-Stepanian, M.; Sun, H., Differential and isomer-specific modulation
of vitamin A transport and the catalytic activities of the RBP receptor by
retinoids. J Membr Biol 2013, 246 (8), 647-60.
- Zhong, M.; Kawaguchi, R.; Ter-Stepanian,
M.; Kassai, M.; Sun, H., Vitamin A transport and the transmembrane pore
in the cell-surface receptor for plasma retinol binding protein. PLoS
One 2013, 8 (11), e73838.
- Terra, R.; Wang, X.; Hu, Y.; Charpentier, T.;
Lamarre, A.; Zhong, M.; Sun, H.; Mao, J.; Qi, S.; Luo, H.; Wu, J., To
Investigate the Necessity of STRA6 Upregulation in T Cells during T Cell Immune
Responses. PLoS One 2013, 8 (12), e82808.<
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- Zhong, M.; Kawaguchi, R.; Kassai, M.; Sun,
H., Apo-RBP, holo-RBP, and insulin resistance. Mol Cell Biol 2014,
34 (11), 2105-6.
- Zhong, M.; Kawaguchi, R.; Kassai, M.; Sun,
H., How free retinol behaves differently from rbp-bound retinol in RBP
receptor-mediated vitamin A uptake. Mol Cell Biol 2014, 34
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- Esmailpour, T.; Riazifar, H.; Liu, L.;
Donkervoort, S.; Huang, V. H.; Madaan, S.; Shoucri, B. M.; Busch, A.; Wu, J.;
Towbin, A.; Chadwick, R. B.; Sequeira, A.; Vawter, M. P.; Sun, G.; Johnston, J.
J.; Biesecker, L. G.; Kawaguchi, R.; Sun, H.; Kimonis, V.; Huang, T., A
splice donor mutation in NAA10 results in the dysregulation of the retinoic
acid signalling pathway and causes Lenz microphthalmia syndrome. J Med
Genet 2014, 51 (3), 185-96.
- Cheng,
G.*; Zhong, M.*; Kawaguchi, R.*; Kassai, M.; Al-Ubaidi, M.; Deng, J.;
Ter-Stepanian, M.; Sun, H., Identification of PLXDC1 and PLXDC2 as the
transmembrane receptors for the multifunctional factor PEDF. eLife
2014, 4 (doi: 10.7554/eLife.05401). *These authors contributed
equally to this work.
- Zhong, M; Sun, H., A Genetic Clog in the Vitamin A Transport Machinery. Cell 2015, 161 (3), 435-437.