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George Sachs, MD
Membrane Biology Laboratory
VA Greater Los Angeles Healthcare System, West LA Medical Center
11301 Wilshire Boulevard
Building 113, Room 324
Los Angeles, CA 90073
310- 268-3923

Research Interests:

Our work is:

  1. On gastric biology of H. pylori using in vivo transcriptome analysis focused on novel methods of eradication using monotherapy including detailed analysis of functions of genes highly upregulated in the stomach.
  2. Structure function of the gastric acid pump and novel inhibitors for clinical use.
  3. Analysis of transcriptomes of purified parietal, ECL and EC cells to discover novel physiology and mechanisms and therapy of irritable bowel syndrome by functional assays of genes found to change under different conditions.
  4. Transcriptome Analysis of normal and carageenin treated rat synovial cells and resident macrophages to discover mechanisms of current therapy of rheumatoid arthritis and find leads for novel treatment.
  5. Crystal structure of the acid gated urea transport protein known to be essential for infection by H. pylori and high throughput screening for inhibitors of this channel.

Representative Publications:

Vagin O, Tokhtaeva E, Sachs G. (2006) The Role of the beta1 Subunit of the Na,K-ATPase and Its Glycosylation in Cell-Cell Adhesion. J Biol Chem. 281(51):39573-87.

Lambrecht NW, Yakubov I, Zer C, Sachs G. (2006) Transcriptomes of purified gastric ECL and parietal cells: identification of a novel pathway regulating acid secretion. Physiol Genomics. 25(1):153-65.

Munson K, Garcia R, Sachs G. (2005) Inhibitor and ion binding sites on the gastric H,K-ATPase. Biochemistry. 44(14):5267-84.