Dr. Kenneth P. Roos
Cardiovascular Physiology
53-151 CHS
310-825-5408
kroos@mednet.ucla.edu
Mouse Physiology Laboratory
Physiology Teaching Laboratory
Heart Lab Homepage
Research Interests:
My research focuses on the phenotypic assessment of cardiovascular function in normal and genetically altered rodent models of disease. I am the director of the Mouse Physiology Laboratory which utilizes a variety of technically challenging “state of the art” methods coupled with biophysical and engineering approaches to reveal a more precise understanding of the structure-function relationship related to heart disease and its pathology. In collaboration with molecular geneticists and clinicians, the mouselab provides a translational bridge from targeted genomic changes and potential therapies to the outcome at the whole animal and cellular levels.
As the manager of the Physiology Teaching Lab, I also have a strong interest in instructional development. The teaching lab is a key component of medical, dental and graduate instruction for the department and the school of medicine. My interests in medical education have focused on the refinement of lab instruction using interactive computer models and human patient simulators.
Representative Publications:
Jordan, M.C., Y. Zheng, N. Rozengurt, S. Ryasantsev, K.P. Roos, E.F. Neufeld. (2005)
Cardiac manifestations in the mouse model of mucopolysaccharidosis I.
Molec. Genetics & Metab., 86:233-243.
Roos, K.P., Jordan, M.C., Fishbein, M.C., Ritter, M.R., Friedlander, M., Chang, H.C., Rahgozar, P., Han, T., Garcia, A.J., MacLellan, W.R., Ross, R.S., Philipson, K.D. (2007)
Hypertrophy and heart failure in mice overexpressing the cardiac sodium-calcium exchanger.
J. Card. Fail., 13(4): 318-29.
Lee, S., Chen, T.T., Barber, C.L., Jordan, M.C., Murdock, J., Desai, S., Ferrara, N., Nagy, A., Roos, K.P., Iruela-Arispe, M.L. (2007)
Autocrine VEGF signaling is required for vascular homeostasis. Cell, 130(4):691-703.
Electrocardiogram (ECG) obtained via radio telemetry from an awake ambulatory mouse.
Isolated Cardiac Myocyte
2-D directed M-mode echocardiograph from transgenic mouse heart.
