Dr. Douglas C. Rees
Adjunct Professor of Physiology
Professor (Caltech)
dcrees@caltech.edu

Research Interests:

Structural bioenergentics; crystallographic analyses of proteins mediating biological energy transduction processes

Representative Publications:

Chang, G., Spencer, R. H., Lee, A. T., Barclay, M. T., and Rees, D. C. "Structure of the MscL Homolog from Mycobacterium tuberculosis: A Gated Mechanosensitive Ion Channel" Science 282, 2220-2226 (1998).

Iverson, T. M., Luna-Chavez, C., Cecchini, G., and Rees, D. C. "Structure of the Escherichia coli Fumarate Reductase Respiratory Complex" Science 284, 1961-1966 (1999).

Spencer, R. H., Chang, G., and Rees, D. C. "Feeling the Pressure: Structural Insights into a Gated Mechanosensitive Channel" Curr. Op. Struct. Biol. 9, 448-454 (1999).

Rees, D. C. and Howard, J. B. "Structural Bioenergetics and Energy Transduction Mechanisms" J. Mol. Biol. 293, 343-350 (1999)

Rees, D. C., Chang, G., and Spencer, R. H. "Crystallographic Analyses of Ion Channels: Lessons and Challenges" J. Biol. Chem. 275, 713-716 (2000).

Representative Publications:

Chen, B.M. and Grinnell, A.D. (1997) Kinetics, Ca++ dependence, and biophysical properties of integrin-mediated mechanical modulation of transmitter release from frog motor neerve terminals. J. Neurosci.  17:904-916

Yazejian, B.M., Sun, X.-P., and Grinnell, A.D. (2000) Tracking presynaptic Ca++ dynamics during neurotransmitter release with Ca++-activated K+ channels. Nature Neurosci. 3:566-571.

Sun, V.-P., Yazejian, B, and Grinnell, A.D. (2004) Electrophysiological properties of BK channels in Xenopus motor nerve terminals. J. Physiol. 557:207-228

Synapse in Xenopus 
Nerve-muscle cell culture

Freeze-etch of frog nmj