Dr. Diane Papazian
Professor
53-159 CHS
310-206-7043
papazian@mednet.ucla.edu

Research interests:

Structure, function, and biology of voltage-gated potassium channels

Representative publications:

Waters, M.F., Minassian, N.A., Stevanin, G., Figueroa, K.P., Bannister, J.P.A., Nolte, D., Mock, A.F., Evidente, V.G., Fee, D., Müller, U., Dürr, A., Brice, A., Papazian, D.M., and Pulst, S.M. (2006) Mutations in the voltage-gated potassium channel KCNC3 cause degenerative and developmental CNS phenotypes.  Nat. Genet. 38, 447-451.

Bannister, J.P.A., Chanda, B., Bezanilla, F., and Papazian, D.M. (2005) Optical detection of rate-determining, ion-modulated conformational changes of the ether-à-go-go K+ channel voltage sensor.  Proc. Natl. Acad. Sci. USA 102, 18718-18723.

Silverman, W.R., Bannister, J.P.A., and Papazian, D.M. (2004) Ion binding site in eag voltage sensor accommodates a variety of ions and is accessible in closed channel. Biophys. J. 87, 3110-3121.

Representative Publications:

Chen, B.M. and Grinnell, A.D. (1997) Kinetics, Ca++ dependence, and biophysical properties of integrin-mediated mechanical modulation of transmitter release from frog motor neerve terminals. J. Neurosci.  17:904-916

Yazejian, B.M., Sun, X.-P., and Grinnell, A.D. (2000) Tracking presynaptic Ca++ dynamics during neurotransmitter release with Ca++-activated K+ channels. Nature Neurosci. 3:566-571.

Sun, V.-P., Yazejian, B, and Grinnell, A.D. (2004) Electrophysiological properties of BK channels in Xenopus motor nerve terminals. J. Physiol. 557:207-228

Synapse in Xenopus 
Nerve-muscle cell culture

Freeze-etch of frog nmj