Dr. Istvan Mody
Tony Coelho Professor of Neurology
Professor of Physiology
3-155 RNRC
310-206-4481
mody@ucla.edu
Visit my Lab

Research Interests:

Synaptic transmission; regulation of ligand-gated ion channels; basic mechanisms of epilepsies; intraneuronal calcium homeostasis

Representative Publications:

Lieberman, D.N. and Mody, I. (1999) Casein kinase II regulates NMDA channel function. Nature Neurosci., 2: 125-132.

Nägerl, U.V., Mody, I., Jeub, M., Lie, A.A., Elger, C.J. and Beck, H. (2000) Surviving granule cells of the sclerotic human hippocampus have reduced Ca2+ influx due to a loss of calbindin-D28k in temporal lobe epilepsy. J. Neurosci., 20: 1831-1836.

Nusser, Z., Naylor, D. and Mody, I. (2001) Synapse-specific contribution of the variation of transmitter concentration to the decay of IPSCs. Biophys. J., 80: 1251-1261.

Jensen, K. and Mody, I. (2001) L-type Ca2+ channel mediated short-term plasticity of GABAergic synapses. Nature Neurosci., 4: 975-976.

Stell, B. and Mody, I. (2002) Receptors with different affinities mediate phasic and tonic GABAA conductances in hippocampal neurons. J. Neurosci., 22: RC223.

Representative Publications:

Chen, B.M. and Grinnell, A.D. (1997) Kinetics, Ca++ dependence, and biophysical properties of integrin-mediated mechanical modulation of transmitter release from frog motor neerve terminals. J. Neurosci.  17:904-916

Yazejian, B.M., Sun, X.-P., and Grinnell, A.D. (2000) Tracking presynaptic Ca++ dynamics during neurotransmitter release with Ca++-activated K+ channels. Nature Neurosci. 3:566-571.

Sun, V.-P., Yazejian, B, and Grinnell, A.D. (2004) Electrophysiological properties of BK channels in Xenopus motor nerve terminals. J. Physiol. 557:207-228

Synapse in Xenopus 
Nerve-muscle cell culture

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