Dr. Robb MacLellan
Associate Professor of Medicine and Physiology
310-825-2556
wrmaclellan@mednet.ucla.edu

Heart Lab Homepage

Research Interests:

Regulation of cardiac myocyte growth

Representative Publications:

MacLellan, W.R., H. Oh, P. Frenkel, A. Garcia, M.C. Jordan, K.P. Roos, and M.D. Schneider (2005) Overlapping roles of pocket proteins in the myocardium are unmasked by germline deletion of p130 plus heart-specific deletion of Rb Mol. Cell. Biol. 25:2486-97.

Goodfellow, S.F., Innes, F., Derblay, L.E., MacLellan, W.R., Scott, P.H., White, R.J. (2006) Regulation of RNA polymerase III transcription during hypertrophic growth.  MBO J. 5:1522-33.

Weiguang Zhong, Songyan Mao, Scott Tobis, Maria C. Jordan, Kenneth P. Roos, Michael C. Fishbein, Ignacio Moreno de Alborán and MacLellan WR. Hypertrophic growth in cardiac myocytes is mediated by a Myc/Cyclin D2-dependent pathway. EMBO J 2006 (in press).

Representative Publications:

Chen, B.M. and Grinnell, A.D. (1997) Kinetics, Ca++ dependence, and biophysical properties of integrin-mediated mechanical modulation of transmitter release from frog motor neerve terminals. J. Neurosci.  17:904-916

Yazejian, B.M., Sun, X.-P., and Grinnell, A.D. (2000) Tracking presynaptic Ca++ dynamics during neurotransmitter release with Ca++-activated K+ channels. Nature Neurosci. 3:566-571.

Sun, V.-P., Yazejian, B, and Grinnell, A.D. (2004) Electrophysiological properties of BK channels in Xenopus motor nerve terminals. J. Physiol. 557:207-228

Synapse in Xenopus 
Nerve-muscle cell culture

Freeze-etch of frog nmj