Dr. H. Ronald  Kaback
Structural Studies & Biophysics
6-720 Macdonal Research Laboratories
310-206-5053
rkaback@mednet.ucla.edu 

Selected Publications:

Ermolova, N.V., Smirnova, I.N., Kasho, V.N. & Kaback, H.R. 2005. Interhelical packing modulates conformational flexibility in the lactose permeae of Escherichia coli. Biochemistry 44: 7669-77.

Kaback, H.R. 2005. Structure and Mechanism of the Lactose Permease. Compt Rendu BIOLOGIE 328: 557-67.

Weinglass, A. B., Soskine, M., Vazquez-Ibar, J. L., Whitelegge, J. P., Faull, K. F.
Kaback, H. R. & Schuldiner, S. 2005. Exploring the role of a unique carboxyl residue in EmrE by mass spectrometry. J. Bio. Chem. 280: 7487-92.

Guan, L., Smirnova, I. N., Verner, G., Nagamoni, S. & Kaback, H. R. 2006. Manipulating phospholipids for crystallization of a membrane transport protein. Proc Natl Acad Sci U S A. 103: 1723-6.

Ermolova, N., Madhvani, R. V. & Kaback, H. R. 2006. Site-directed alkylation of cysteine replacements in the lactose permease of Escherichia coli: helices I, III, VI, and XI. Biochemistry 45: 4182-9.

Mirza, O., Guan, L., Verner, G., Iwata, S. & Kaback, H. R. 2006. Structural evidence for induced fit and a mechanism for sugar/H(+) symport in LacY. EMBO J 25: 1177-83.

Kasho, V. N., Smirnova, I. N. & Kaback, H. R. 2006. Sequence alignment and homology    threading reveals prokaryotic and eukaryotic proteins similar to lactose permease.J Mol Biol 358: 1060-70.

Vadyvaloo, V., Smirnova, I. N., Kasho, V. N. & Kaback, H.R. 2006. Conservation of  residues involved in sugar/H(+) symport by the sucrose permease of Escherichia coli relative to lactose permease. J Mol Biol 358: 1051-9.

Yiling Nie, Irina Smirnova, Vladimir Kasho & Kaback, H.R. 2006. Energetics of ligand-induced  conformational flexibility in the lactose permease of Escherichia coli. J Biol Chem 281: 35779-84.

Smirnova, I.N., Kasho, V.N. & Kaback, H.R. 2006. Direct sugar binding to LacY measured by resonance energy transfer. Biochemistry, in press.

Kaback, H. R., Dunten, R. L., Frillingos, S., Venkatesan, P., Kwaw, I., Zhang, W., Ermolova, N. 2006, Site-directed alkylation and the alternating access model for LacY. Proc Natl Acad Sci USA, in press.