Dr. Earl Homsher
Professor
53-232 CHS
310-825-6976
ehomsher@mednet.ucla.edu

Research Interests:

Regulation of contraction; single motor molecule force displacement measurements; the molecular biology of hypertrophic cardiomyopathy; single myofibril mechanics and kinetics; and in vitro motility

Representative Publications:

Takagi, Y, E. Homsher, Y.E. Goldman, and H. Shuman (2006) Force generation in single conventional actomyosin complexes under high dynamic load.  Biophys.J. 90:1295-307.

Pirhoddi, N., C. Tesi,  M.A. Pellegrino,  L.S. Tobacman, E. Homsher, and C. Poggesi. (2003). Contractile effects of the exchange of cardiac troponin for fast skeletal troponin in rabbit psoas single myofibrils.  J. Physiol. 552:205-215.

Heller, M., M. Nili, E. Homsher, and L.S. Tobacman (2003). Cardiomyopathic tropomyosin mutations that increase thin filament Ca2+-sensitivity and tropomyosin N-domain flexibility. J Biol Chem. 278:41741-41748.

Representative Publications:

Chen, B.M. and Grinnell, A.D. (1997) Kinetics, Ca++ dependence, and biophysical properties of integrin-mediated mechanical modulation of transmitter release from frog motor neerve terminals. J. Neurosci.  17:904-916

Yazejian, B.M., Sun, X.-P., and Grinnell, A.D. (2000) Tracking presynaptic Ca++ dynamics during neurotransmitter release with Ca++-activated K+ channels. Nature Neurosci. 3:566-571.

Sun, V.-P., Yazejian, B, and Grinnell, A.D. (2004) Electrophysiological properties of BK channels in Xenopus motor nerve terminals. J. Physiol. 557:207-228

Synapse in Xenopus 
Nerve-muscle cell culture

Freeze-etch of frog nmj