Mouse Physiology Laboratory


UCLA is a recognized leader in genomics. The molecular techniques to modify the mouse genotype have developed far more rapidly than those to assess the resulting phenotype. The major impediment to progress has been difficulty in adapting standard measurement tools to the small size of the mouse. The UCLA Mouse Physiology Laboratory has met the challenge with studies on numerous knock-in, knock-out, or spontaneously mutated mouse models that manifest cardiac and neuro-regulatory phenotypes. The lab additionally evaluates cardiovascular function in rat models of heart failure or regenerative stem cell therapy following surgically induced myocardial infarction.

The Mouse Physiology Laboratory (a UCLA Biosciences Core Facility) brings together researchers of multiple disciplines to link genes to function in the whole animal. A wide variety of procedures and protocols are available to assess rodent phenotypes. Dr. Roos and the mouselab staff are interested in working with the investigator in developing new approaches for phenotypic analysis. The facility is available to all UCLA investigators as well as outside investigators. It is our goal to work closely with each investigator to obtain the best possible evaluation of their model. Each investigator is encouraged to participate fully in the lab during the study.

The Mouse Physiology Laboratory was started in 1998 within the Department of Physiology in association with the Cardiovascular Research Lab at the David Geffen School of Medicine at UCLA. The core was established with funds from the UCLA Laubisch Endowment. Fees paid by the individual users support the daily operations of the core.