Mouse Physiology Laboratory

Autonomic Testing

The autonomic nervous system (ANS) is the key regulator of blood pressure, heart rate, heart rate variability (HRV), respiratory rate and many other aspects of normal physiological function. The mouse physiology laboratory can evaluate several aspects of autonomic function in your animal models via hemodynamic and telemetric measurements.

The sensitivity of the baroreceptors for pressure and heart rate regulation can be evaluated in catheterized or telemetry implanted animals by serial injections of angiotensin II, phenylephrine and sodium nitroprusside. We can perform analysis of heart rate variability in the both time and frequency domains to reveal any ANS dysfunction in telemetry implanted animals. We can also monitor pressure during periods of exercise, induced stress or postural changes.